In any large city there are places where personal crime happens far more often than others, and your planning should start with a) knowing where those are and b) not going there if you can avoid doing so.
Of course none of this precludes an attack from happening in even the "best" neighborhoods, and I'm not saying that it does; only that there are places you can go where you are statistically safer than others, and you'd be foolish not to pick one of those if you possibly can!
...On arrival you can almost always reject a room on the first or second floor (which are much easier for a window-based entry); get one closer to the elevator (where there is more traffic and less opportunity to clandestinely break in); and swap for one without an adjoining room accessible through a doorway (which gives you yet another entry point to cover.)
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